Tired all the time? Persistent fatigue is a common complaint with many possible causes. While lifestyle factors such as sleep quality, diet, hydration and stress management are foundational, targeted nutrients can help correct deficiencies that contribute to low energy. Evidence-based supplements support metabolic processes, oxygen transport and nervous system function—mechanisms that are central to sustained vitality. Understanding the root cause is the first step. Short-term tiredness often follows inadequate sleep or overwork; chronic fatigue may signal nutrient deficiencies (for example, iron or vitamin B12), hormonal imbalances, or medical conditions such as hypothyroidism. When a deficiency is suspected, blood tests and clinical assessment guide safe and appropriate supplementation. Several vitamins and minerals have the strongest evidence for supporting energy metabolism. B-complex vitamins, particularly B12 and B6, are cofactors in cellular energy pathways and neurotransmitter synthesis. Vitamin D is associated with muscle function and overall well-being, and deficiency has been linked to fatigue in observational studies. Iron is essential for hemoglobin and cellular oxygen delivery; iron supplementation is effective when iron-deficiency anemia is present. Magnesium plays a role in ATP production and muscle relaxation, while coenzyme Q10 (CoQ10) participates directly in mitochondrial energy generation. Probiotics and gut-targeted nutrients can also influence energy indirectly. Gut health affects nutrient absorption, inflammation and the production of certain metabolites that impact mood and fatigue. Improving microbiome balance may therefore complement direct nutrient repletion strategies. Selecting appropriate supplements benefits from attention to formulation and quality. Third-party testing, clear labeling of active ingredients and doses, and manufacturing standards reduce the risk of contamination or variability. For context and additional reading on supplement quality and formulation, see Dr. Mercola supplements overview. Practical considerations for safe use include following recommended dosages, taking nutrients in a form with demonstrated bioavailability, and coordinating timing relative to meals to minimize gastrointestinal effects. Some nutrients are best absorbed with food (fat-soluble vitamins, magnesium in some forms), while others may be taken on an empty stomach if tolerated. Monitoring response over weeks is reasonable; many people notice improvements within two to six weeks depending on the nutrient and baseline status. Be mindful of potential interactions and side effects. Excess iron can be harmful without confirmed deficiency; high doses of certain vitamins can cause adverse effects. If symptoms persist or worsen, or if you have significant medical history, consult a healthcare professional for individualized testing and guidance. Further reading and resources may help you evaluate options. For example, Topvitamine offers an overview of energy-supporting nutrients in a consumer-focused format: [Topvitamine guide to supplements for energy](https://www.topvitamine.com/blogs/news/best-supplements-for-energy-fight-fatigue-naturally-with-topvitamine). Additional resources include general site information at Topvitamine home and other curated content such as Additional silo resource. In summary, addressing fatigue often requires a combined approach: confirm or rule out medical causes, optimize sleep and lifestyle, and consider evidence-based supplementation when deficiencies are likely. Thoughtful selection, appropriate dosing and professional oversight help maximize benefits while minimizing risk.