# Dr. Mercola Liposomal Vitamin C: Superior Absorption Compared to Regular Vitamin C Vitamin C plays multiple roles in human health, including supporting immune function, acting as an antioxidant, and contributing to collagen synthesis for skin and connective tissues. Absorption efficiency varies across supplement forms, and liposomal formulations are designed to address limitations of conventional ascorbic acid products. For an overview of this specific formulation see [Dr. Mercola liposomal vitamin C](https://www.topvitamine.com/blogs/news/dr-mercola-liposomal-vitamin-c-better-absorption-for-superior-health). ## What is liposomal vitamin C? Liposomal vitamin C uses microscopic phospholipid vesicles (liposomes) to encapsulate ascorbic acid. The lipid composition resembles cell membranes, which can protect vitamin C from degradation in the gastrointestinal tract and facilitate transport across the intestinal barrier. In theory and in several pharmacokinetic studies, this delivery system can lead to higher plasma vitamin C concentrations than equivalent doses of non-encapsulated vitamin C. ## Mechanism and bioavailability evidence Conventional oral vitamin C absorption is mediated by sodium-dependent transporters in the small intestine and is limited at high doses; excess amounts may be excreted in urine or cause gastrointestinal upset. Liposomal delivery bypasses some of these constraints by protecting the nutrient as it passes through the stomach and facilitating cellular uptake. Clinical and experimental studies report that liposomal preparations can achieve higher blood levels at similar or lower doses than standard formulations, although absolute differences may vary by product and study design. As with many supplements, individual responses differ and further high-quality randomized trials would strengthen understanding of long-term clinical benefits. ## Benefits and tolerability Because liposomal vitamin C can increase systemic availability, potential benefits include enhanced antioxidant support and improved availability for processes like collagen production. Some users report reduced gastrointestinal side effects compared with large-dose conventional vitamin C, likely because the encapsulation minimizes direct mucosal irritation and avoids overwhelming transporter-mediated absorption. These outcomes align with mechanistic expectations, though clinical endpoints (e.g., infection frequency or skin health outcomes) require targeted clinical study for confirmation. ## Formulation quality and considerations Product quality matters for liposomal supplements: phospholipid source, particle size, and manufacturing controls influence stability and bioavailability. Consumers and clinicians often review labels for non-GMO sources, absence of common allergens, and independent quality testing. For context on complementary nutrient strategies, see the probiotics overview at Probiotics from A to Z and considerations for plant-based diets at Best supplements for a vegan diet. ## Dosage guidance and safety Reported dosing for liposomal vitamin C varies; some formulations provide around 1,000 mg per serving. Starting at a lower dose to assess tolerance and consulting a healthcare professional for personalized advice is prudent, particularly for individuals with kidney disease or specific metabolic conditions. Monitoring total vitamin C intake from diet and supplements helps avoid unnecessary excess. ## Summary Liposomal vitamin C represents a delivery approach intended to improve oral bioavailability compared with regular vitamin C. Evidence indicates enhanced plasma levels and improved gastrointestinal tolerability for many users, though outcomes depend on product quality and individual factors. For general information about suppliers and platforms providing supplements, see Topvitamine.