Introduction

Turning 60 often prompts a reassessment of nutritional priorities because age-related changes can affect absorption, metabolism, and requirements of key nutrients. Reduced skin synthesis of vitamin D, diminished gastric acid and intrinsic factor that impair vitamin B12 uptake, changes in renal function, and polypharmacy are common factors that influence which vitamins merit attention. A pragmatic, evidence-based approach emphasizes a food-first strategy supported by targeted, test-guided supplementation when warranted.

Key vitamins and nutrients for people in their 60s

Several nutrients are commonly prioritized for adults around 60 due to their roles in bone health, energy metabolism, immune function, and cognitive maintenance:

• Vitamin D: Important for calcium and phosphorus metabolism, bone integrity, and muscle function. Because cutaneous production declines with age and sun exposure may be limited, many older adults benefit from assessment of serum 25-hydroxyvitamin D and individualized supplementation as indicated.
• Vitamin B12: Critical for nervous system function and reduction of fatigue. Age-related absorption issues and certain medications (e.g., metformin, proton pump inhibitors) increase the risk of deficiency; screening and replacement are often appropriate.
• Calcium, magnesium, and vitamin K2: These minerals and cofactors support bone mineralization and proper calcium utilization. Clinical context (kidney function, medications such as anticoagulants) guides dosing choices.
• Omega-3 fatty acids (DHA/EPA): Associated with cardiovascular and brain health; dietary intake from fatty fish is preferred, with supplements considered when intake is low.
• Antioxidants (vitamin C, vitamin E) and B-complex vitamins: Support cellular protection from oxidative stress and energy-yielding metabolism. Whole-food sources should be prioritized, with supplements used to correct documented shortfalls.

Personalization and safety

Individual factors—dietary patterns (e.g., vegan diets), chronic conditions (diabetes, kidney disease, osteoporosis), medication regimens, and laboratory values—determine which supplements are appropriate. For example, vegans typically require reliable vitamin B12 sources, while those with low sun exposure or darker skin pigmentation often need vitamin D support. Clinicians commonly use serum 25(OH)D, serum B12 (and methylmalonic acid when needed), and standard metabolic panels to guide therapy. Avoid high-dose, long-term supplementation without clinical justification because fat-soluble vitamins can accumulate and minerals rely on renal clearance.

Practical nutrition strategies

Focus on nutrient-dense foods: oily fish, dairy or fortified alternatives, legumes, leafy greens, nuts, seeds, whole grains, and a variety of fruits and vegetables. When supplementation is needed, choose transparent formulations and consider third-party testing. For concise guidance tailored to specific concerns, consult evidence-based resources such as the overview on which vitamin is recommended at age 60 (which vitamin is recommended at 60), or a focused review on how vitamin B12 supports skin and aging (vitamin B12 and skin health).

For those curious about timing and compatibility of supplements with dietary patterns, see practical considerations about supplementation practices (supplements during intermittent fasting) and a related primer on fasting and supplement use (intermittent fasting and supplements overview). General information about product categories can be found on the TopVitamins site (TopVitamins).

Conclusion

There is no single universal vitamin for everyone at age 60. Vitamin D and B12 are frequently prioritized because of common age-related deficits, but optimal choices depend on diet, health status, medications, and laboratory results. A measured, individualized strategy—food-first, test-guided supplementation, and clinical oversight—helps maximize benefits while minimizing risks.